07-2192

Anti-phospho-TBK1 (Ser172) Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, human
• 종 반응성(상동성에 의해 예측): rat (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_037386
• UniProt 수납 번호: Q9UHD2
• 배송 상태: wet ice
• 타겟 번역 후 변형: phosphorylation (pSer172)
• 유전자 정보: human ... TBK1(29110)

설명

일반 설명

TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.

특이성

This antibody recognizes TBK1 phosphorylated at Ser172.

면역원

KLH-conjugated linear peptide corresponding to human TBK1 phosphorylated at Ser172.

애플리케이션

This phospho-TBK1 antibody is validated for use in WB for the detection of the phospho-TBK1 protein.

품질

Evaluated by Western Blot in EGF treated and untreated HEK293 cell lysates.

Western Blot Analysis: 1:1,000 dilution of this antibody detected TBK1 on 10 µg of EGF treated and untreated HEK293 cell lysates.

표적 설명

~90 kDa observed

분석 메모

Control
EGF treated and untreated HEK293 cell lysates

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable