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Merck
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주요 문서

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C-108

Supelco

Cyclosporin D solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

동의어(들):

1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution

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모든 사진(1)

About This Item

CAS Number:
63775-96-2
EC Number:
200-835-2
MDL number:
MFCD11111526
UNSPSC 코드:
41116107
PubChem Substance ID:
329774843
NACRES:
NA.24

Grade

certified reference material

Quality Level

300

양식

liquid

특징

Snap-N-Spike®/Snap-N-Shoot®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

농도

1.0 mg/mL in acetonitrile

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

clinical testing

형식

single component solution

저장 온도

−70°C

SMILES string

C\C=C\C[C@@H](C)[C@@H](O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C

InChI

1S/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46?,47+,49+,50+,51+,52+,53-/m1/s1

InChI key

ZNVBEWJRWHNZMK-UPMQNEEPSA-N

관련 카테고리

일반 설명

An internal standard for clinical testing of Cyclosporin A by LC-MS/MS. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within Cyclosporin A′s narrow therapeutic range. The Snap-N-Spike® format allows laboratories to eliminate weighing operations of these hazardous substances, significantly reducing occupational exposure hazards related to handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

FlameExclamation mark
GHS02,GHS07

신호어

Danger

유해 및 위험 성명서

H225,H302 + H312 + H332,H319

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

35.6 °F - closed cup

Flash Point (°C)

2 °C - closed cup

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

[The effects of cyclosporine G and D treatment on experimental autoimmune uveoretinitis and kidney in rats].
H Kawashima et al.
Nippon Ganka Gakkai zasshi, 91(10), 940-950 (1987-10-01)
Shinpei Murasawa et al.
Bioorganic & medicinal chemistry, 20(21), 6384-6393 (2012-10-03)
A structure consisting of substituted hydantoin linked to a 5-(halophenyl)furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular-weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-3-yl)methyl]imidazolidin-1-yl}-2-furamide (17)
Norman B Roberts et al.
Clinical chemistry and laboratory medicine, 43(2), 228-236 (2005-04-22)
The problem in the measurement of cyclosporin (CyA) is that the widely used immuno-based assays suffer from interference by metabolites present in unpredictable excess. To resolve this, the consensus view has been to develop more specific and robust procedures for
T M Annesley et al.
Therapeutic drug monitoring, 14(5), 397-401 (1992-10-01)
A sensitive high-performance liquid chromatographic method for the analysis of the immunosuppressant cyclosporin G (OG 37-325, Nva2-cyclosporine, CsG) in whole blood has been developed. Sample preparation, employing cyclosporin A (CsA) as internal standard, involves organic extraction with methyl t-butyl ether
M Gschwendt et al.
Biochemical and biophysical research communications, 150(2), 545-551 (1988-01-29)
Various biological effects induced by the tumor promoting phorbol ester TPA in mouse skin are comparably suppressed by the immunologically inactive cyclosporine H (CsH) and by the strongly immunosuppressive cyclosporine A (CsA). These effects inhibited include the development of edema
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