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Merck
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주요 문서

810262P

Avanti

C11 TopFluor™ Ceramide

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder

동의어(들):

N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C42H70N3O3F2
CAS Number:
1246355-58-7
Molecular Weight:
703.02
MDL number:
MFCD22416770
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 250 μg (810262P-250ug)

제조업체/상표

Avanti Research™ - A Croda Brand 810262P

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.

애플리케이션

C11 TopFluor™ Ceramide may be used:
  • in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
  • as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
  • to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy

생화학적/생리학적 작용

Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.

포장

5 mL Amber Glass Screw Cap Vial (810262P-250ug)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)

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