700140P

6-keto-5α-hydroxycholesterol

Avanti Research^™ - A Croda Brand 700140P, powder

• 동의어(들): 3β,5α-dihydroxy-cholestan-6-one
• 실험식(Hill 표기법): C₂₇H₄₆O₃
• CAS Number: 13027-33-3
• Molecular Weight: 418.65
• MDL number: MFCD00271438
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 5 mg (700140P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 700140P
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O[C@]21[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)CC2=O)(CC[C@@H](C1)O)C
• InChI: 1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1
• InChI key: SJZZRXMQSAXCFD-ZCBMJONGSA-N

설명

일반 설명

6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol.

생화학적/생리학적 작용

6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes.

포장

5 mL Amber Glass Screw Cap Vial (700140P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids