추천 제품
설명
Di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt)
분석
>99% (HPLC)
양식
powder
포장
pkg of 1 × 1 mg (699500P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand
응용 분야
lipidomics
지질 유형
bioactive lipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO[C@]2(C([O-])=O)C[C@@H](O[C@@]3(C([O-])=O)O[C@H]([C@H](O)CO)[C@H](O)[C@H](O)C3)[C@@H](O)[C@@H]([C@H](O)CO)O2)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCC
일반 설명
A new preparation of the saccharolipid glycan, Kdo2-Lipid A (KLA), is a nearly homogeneous Re lipopolysaccharide (LPS) substructure with endotoxin activity equal to that of native LPS. KLA is comparable to LPS and its activity is reduced by >103 in cells from TLR-4 deficient mice. The advantage of KLA over LPS is that it is a reproducible, defined natural product, and it can be detected by ESI/MS at the low concentrations used to stimulate animal cells. The purity of KLA should also facilitate the structural analysis of its complexes with signaling receptors, such as TLR-4/MD2. New research* shows 1μg KLA induces the same response as 10μg LPS.Perform experiments at half the cost of using LPS!
Kdo2-Lipid A is a natural endotoxin and a combination of oligosaccharide and lipid.
애플리케이션
Kdo2-Lipid A (KLA) has been used to study its role in lipopolysaccharide induced prion protein conversion.
Kdo2-Lipid A (KLA) has been used:
- as a toll like receptor (TLR) ligand source in immortalized murine macrophage culture media
- in 2H-,13C-,15N-labeled OprHΔL1ΔL4 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles, to determine the specific residues of OprHΔL1ΔL4 interacting with lipopolysaccharides (LPS) source
- as a component of LPS stock to study its role in lipopolysaccharide induced prion protein conversion
생화학적/생리학적 작용
Kdo2-Lipid A might be useful to stimulate inflammatory response.
포장
2 mL Amber Glass Crimp Cap Vial (699500P-1mg)
기타 정보
For R&D use only. Not for drug, household, or other uses.
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
No data available
Flash Point (°C)
No data available
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이미 열람한 고객
Sophie R Liebergall et al.
Molecular and cellular biology, 40(2) (2019-10-30)
Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages
Maurya MR, et al.
Journal of Lipid Research, 54(9), 2525-2542 (2013)
Molecular interactions of lipopolysaccharide with an outer membrane protein from Pseudomonas aeruginosa probed by solution NMR
Kucharska I, et al.
Biochemistry, 55(36), 5061-5072 (2016)
Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversion
Ladner-Keay CL, et al.
Prion, 10(6), 466-483 (2016)
Alexander Y Andreyev et al.
Journal of lipid research, 51(9), 2785-2797 (2010-06-25)
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual lipids. We report an analysis of the subcellular
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