936189

AdQPhos

• 동의어(들): 1,2,3,4,5-Pentaphenyl-1′-(di-adamantylphosphino)ferrocene
• 실험식(Hill 표기법): C₆₀H₅₉FeP
• Molecular Weight: 866.93
• UNSPSC 코드: 12352142
• NACRES: NA.22

속성

• 분석: ≥90%
• Quality Level: 100
• 반응 적합성: reaction type: Cross Couplings
• 환경친화적 대안 제품 특성: Catalysis; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• 작용기: phosphine
• 환경친화적 대안 카테고리: Aligned
• SMILES string: C=1C=CC(=CC1)C=23C4(C=5C=CC=CC5)=C6(C=7C=CC=CC7)[C-]8(C=9C=CC=CC9)C2(C=%10C=CC=CC%10)[Fe+2]%11%12%13%143468[CH]=%15[CH]%14=[CH]%13[C-]%12(P(C%16%17CC%18CC(CC(C%18)C%16)C%17)C%19%20CC%21CC(CC(C%21)C%19)C%20)[CH]%15%11
• InChI: InChI=1S/C35H25.C25H34P.Fe/c1-6-16-26(17-7-1)31-32(27-18-8-2-9-19-27)34(29-22-12-4-13-23-29)35(30-24-14-5-15-25-30)33(31)28-20-10-3-11-21-28;1-2-4-23(3-1)26(24-11-17-5-18(12-24)7-19(6-17)13-24)25-14-20-8-21(15-25)10-22(9-20)16-25;/h1-25H;1-4,17-22H,5-16H2;/q2*-1;+2
• InChI key: IQEGBICLOWIZDH-UHFFFAOYSA-N

설명

일반 설명

The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.

Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

애플리케이션

In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable