930083

2-(Pyrimidin-5-yl)phenol

≥95%

• 동의어(들): Maiti-Bag-Dutta Auxiliary
• 실험식(Hill 표기법): C₁₀H₈N₂O
• CAS Number: 18313-50-3
• Molecular Weight: 172.18
• MDL number: MFCD06802618
• UNSPSC 코드: 12352100
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: powder
• mp: 173 °C
• 저장 온도: −20°C

설명

애플리케이션

2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.

2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity.

기타 정보

Arene diversification through distal C(sp2)−H functionalization
Palladium-Catalyzed meta-C–H Allylation of Arenes: A Unique Combination of a Pyrimidine-Based Template and Hexafluoroisopropanol

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable