919950

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine

>98%

• 동의어(들): b-Tz, Minimal tetrazine
• 실험식(Hill 표기법): C₁₆H₁₄N₄S
• CAS Number: 2378619-75-9
• Molecular Weight: 294.37
• MDL number: MFCD33021752
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: >98%
• 양식: powder
• 반응 적합성: reaction type: click chemistry
• SMILES string: S(Cc2ccc(cc2)c3ccccc3)c1nnc(nn1)C
• InChI key: YATUIOCNNCZRCH-UHFFFAOYSA-N

설명

애플리케이션

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here, Lambert et al demonstrated the linker-free incorporation of b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.

Supporting products
PdCl₂(dppf): 697230
Ag₂O: 226831

기타 정보

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable