추천 제품
분석
≥95%
양식
liquid
반응 적합성
reagent type: cross-linking reagent
refractive index
n/D 1.4492
density
1.04746 g/mL
작용기
ester
hydroxyl
저장 온도
2-8°C
SMILES string
O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
InChI
1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
InChI key
FJRDXEGYAVAMLB-UHFFFAOYSA-N
관련 카테고리
애플리케이션
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
기타 정보
법적 정보
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
관련 제품
제품 번호
설명
가격
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Michael L Miller et al.
Journal of medicinal chemistry, 47(20), 4802-4805 (2004-09-17)
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or C-7 position
Synthesis of novel heterobifunctional isocyanato cross-linkers and their applications for the preparation of 10-hydroxycamptothecin and SN-38 conjugates with melanotransferrin P97.
Li Z, et al.
Synthetic Communications, 37(11) (2007)
Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology.
Mei D, et al
Tetrahedron, 67(12), 2251-2259 (2011)
A new route for the synthesis of 1-amino-3,6,9,12-?tetraoxapentadecan-15-oic acid.
Wu X, et al.
J. Chem. Res. (M), 40(6), 368-370 (2016)
Nico Rublack et al.
Journal of nucleic acids, 2011, 805253-805253 (2011-10-21)
Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying
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