711489

1-Hydroxybenzotriazole hydrate

wetted with not less than 20 wt. % water, 97% dry basis

• 동의어(들): HOBt Hydrate
• 실험식(Hill 표기법): C₆H₅N₃O · xH₂O
• CAS Number: 123333-53-9
• Molecular Weight: 135.12 (anhydrous basis)
• Beilstein: 4515
• EC Number: 219-989-7
• MDL number: MFCD00065690
• UNSPSC 코드: 12352000
• PubChem Substance ID: 329763060
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: 97% dry basis
• 양식: powder
• 품질: wetted with not less than 20 wt. % water
• 구성: Water content, ~20%
• 반응 적합성: reaction type: Addition Reactions
• mp: 155-158 °C (lit.)
• solubility: DMF: 0.1 g/mL, clear
• SMILES string: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChI key: PJUPKRYGDFTMTM-UHFFFAOYSA-N

설명

일반 설명

1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.

애플리케이션

1-Hydroxybenzotriazole hydrate is used as an additive:

• In the oligonucleotide couplings.
• In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).

1-Hydroxybenzotriazole hydrate can also be used:

• In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H207,H319,H412
• 예방조치 성명서: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Hazard Classifications: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• Storage Class Code: 4.1A - Other explosive hazardous materials
• WGK: WGK 1
• Flash Point (°F): 314.6 °F
• Flash Point (°C): 157 °C
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges