170216
Methylglyoxal 1,1-dimethyl acetal
≥97%
동의어(들):
1,1-Dimethoxyacetone, Pyruvaldehyde-1-dimethyl acetal, Pyruvic aldehyde dimethyl acetal
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모든 사진(1)
About This Item
Linear Formula:
CH3COCH(OCH3)2
CAS Number:
Molecular Weight:
118.13
Beilstein:
1560557
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
Quality Level
분석
≥97%
양식
liquid
refractive index
n20/D 1.398 (lit.)
bp
143-147 °C (lit.)
density
0.976 g/mL at 25 °C (lit.)
작용기
acetal
ether
ketone
SMILES string
COC(OC)C(C)=O
InChI
1S/C5H10O3/c1-4(6)5(7-2)8-3/h5H,1-3H3
InChI key
ULVSHNOGEVXRDR-UHFFFAOYSA-N
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애플리케이션
Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point (°F)
78.8 °F - closed cup
Flash Point (°C)
26 °C - closed cup
개인 보호 장비
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
이미 열람한 고객
K Ispolnov et al.
Journal of applied microbiology, 104(4), 1092-1102 (2008-01-16)
The purpose of this study was to investigate the behaviour of Saccharomyces cerevisiae in response to extracellular methylglyoxal. Cell survival to methylglyoxal and the importance of phosphates was investigated. The role of methylglyoxal detoxification systems and methylglyoxal-derived protein glycation were
Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism.
Ricardo A Gomes et al.
The FEBS journal, 272(17), 4521-4531 (2005-09-01)
Methylglyoxal is the most important intracellular glycation agent, formed nonenzymatically from triose phosphates during glycolysis in eukaryotic cells. Methylglyoxal-derived advanced glycation end-products are involved in neurodegenerative disorders (Alzheimer's, Parkinson's and familial amyloidotic polyneurophathy) and in the clinical complications of diabetes.
Ajit Ghosh et al.
Scientific reports, 6, 18358-18358 (2016-01-07)
Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced glutathione (GSH). However, in bacteria, glyoxalase III (GLY III) with DJ-1/PfpI domain(s) can do
Svetlana I Dorovskikh et al.
Biomedicines, 9(8) (2021-08-28)
This work is aimed at developing the modification of the surface of medical implants with film materials based on noble metals in order to improve their biological characteristics. Gas-phase transportation methods were proposed to obtain such materials. To determine the
Daniel Prantner et al.
Journal of leukocyte biology, 109(3), 605-619 (2020-07-18)
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septic shock have significantly elevated circulating MG
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