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Key Documents

SAB4300229

Sigma-Aldrich

Anti-phospho-BCL2L11 (pSer69) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BAM antibody produced in rabbit, Anti-BCL2-like 11 (apoptosis facilitator) antibody produced in rabbit, Anti-BIM antibody produced in rabbit, Anti-BIM-alpha6 antibody produced in rabbit, Anti-BIM-beta6 antibody produced in rabbit

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About This Item

MDL number:
MFCD02095895
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~23 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(P-A-SP-P-G)

NCBI accession no.

NP_006529.1

UniProt accession no.

O43521

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer69)

Gene Information

human ... BCL2L11(10018)

Immunogen

Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G), according to the protein BCL2L11.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951411288

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Melkon Iradyan et al.
Cancers, 11(8) (2019-08-04)
Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations, secondary effects, and low ability
Wadie D Mahauad-Fernandez et al.
Cell death & disease, 8(3), e2687-e2687 (2017-03-17)
Almost all breast tumors express the antiviral protein BST-2 with 67%, 25% and 8.2% containing high, medium or low levels of BST-2, respectively. Breast tumor cells and tissues that contain elevated levels of BST-2 are highly aggressive. Suppression of BST-2

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