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Key Documents

SAB4300206

Sigma-Aldrich

Anti-phospho-GJA1 (pSer368) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CX43 antibody produced in rabbit, Anti-DFNB38 antibody produced in rabbit, Anti-GJAL antibody produced in rabbit, Anti-ODDD antibody produced in rabbit, Anti-gap junction protein, alpha 1, 43kDa antibody produced in rabbit

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About This Item

MDL number:
MFCD00803532
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~43 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(R-A-SP-S-R)

NCBI accession no.

NP_000156.1

UniProt accession no.

P17302

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer368)

Gene Information

human ... GJA1(2697)

Immunogen

Peptide sequence around phosphorylation site of serine 368 (R-A-S(p)-S-R), according to the protein GJA1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951411258

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Wenying Wang et al.
Experimental and therapeutic medicine, 17(3), 1847-1854 (2019-02-21)
Cx43 has been documented to be involved in ischemic preconditioning (IPC). However, the participation of Cx43-formed hemichannels in IPC and the potential underlying mechanisms remain unclear. The present study focused on cardiomyocytes' volume regulation during IPC to investigate the role
Hyung Joon Cho et al.
Frontiers in molecular neuroscience, 10, 410-410 (2018-01-10)
Despite successful control of viremia by combined antiretroviral therapy, brain infection and its resulting neurocognitive impairment remain a prevalent comorbidity in HIV infected individuals. HIV invades the brain early in the course of infection via penetration through the blood-brain barrier
Kailing Yang et al.
Frontiers in neurology, 11, 888-888 (2020-09-29)
Objective: Synaptic plasticity is critical for neurorehabilitation after focal cerebral ischemia. Connexin 43 (Cx43), the main component of the gap junction, has been shown to be pivotal for synaptic plasticity. The objective of this study was to investigate the role
Hsiang-Chun Lee et al.
Scientific reports, 7(1), 12050-12050 (2017-09-25)
Very-low-density lipoproteins (VLDL) is a hallmark of metabolic syndrome (MetS) and each manifestation of MetS is related to atrial fibrillation (AF) risks. Slowed atrial conduction is a mechanism of AF in MetS. We hypothesized that VLDL can modulate and reduce
Patrick J Calhoun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 9694-9712 (2020-06-03)
Adenoviruses are responsible for a spectrum of pathogenesis including viral myocarditis. The gap junction protein connexin43 (Cx43, gene name GJA1) facilitates rapid propagation of action potentials necessary for each heartbeat. Gap junctions also propagate innate and adaptive antiviral immune responses
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