L1012

Acido linoleico

liquid, BioReagent, suitable for cell culture

• Sinonimo/i: acido cis-9,cis-12-octadecadienoico
• Formula condensata: CH₃(CH₂)₄CH=CHCH₂CH=CH(CH₂)₇CO₂H
• CAS Number: 60-33-3
• Peso molecolare: 280.45
• Beilstein: 1727101
• Numero CE: 200-470-9
• Numero MDL: MFCD00064241
• Codice UNSPSC: 12352211
• eCl@ss: 32190102
• ID PubChem: 24896270
• NACRES: NA.75

Proprietà

• Origine biologica: plant (Safflower oil)
• Livello qualitativo: 200
• Nome Commerciale: BioReagent
• Saggio: ≥98%
• Stato: liquid
• tecniche: cell culture | mammalian: suitable
• Indice di rifrazione: n20/D 1.466 (lit.)
• P. ebollizione: 229-230 °C/16 mmHg (lit.)
• Punto di fusione: −5 °C (lit.)
• Solubilità: NaOH: 1 M; ethanol: soluble
• Densità: 0.902 g/mL at 25 °C (lit.)
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(CCCCCCC/C=C\C/C=C\CCCCC)=O
• InChI: 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-; OYHQOLUKZRVURQ-HZJYTTRNSA-N
• Informazioni sul gene: human ... SOAT1(6646), SOAT2(8435)

Descrizione

Descrizione generale

Linoleic acid (LA) is the precursor for the synthesis of arachidonic prostaglandins and other eicosanoids. LA is present in vegetable oils and meat.

Applicazioni

Fatty acid that is typically bound to a carrier molecule such as BSA or cyclodextrin for use in cell culture.

Linoleic acid has been used as a component of S12 medium for cardiomyocytes differentiation, minimum essential medium α for spermatogonial stem cell culture and for endothelial differentiation of mouse adipose-derived stem cells (mASC).

Azioni biochim/fisiol

L′acido linoleico aumenta la proliferazione cellulare e l′espressione genica del PPARα e dei suoi geni bersaglio come l′acil-CoA ossidasi negli epatociti primari di anatra .

Linoleic acid (LA) may improve wound healing in diabetic rat. The levels of LA in adipose tissue and platelets are correlated with coronary artery disease. It may induce tumor and apoptosis in colorectal cancer cells. Studies also support their protective effects in lymphocytes. Linoleic acid is typically bound to a carrier molecule such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Confezionamento

Sealed ampule.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)