P0409

Prostaglandin E₂

Name: Prostaglandin E<SUB>2</SUB>
Brand: SIGMA

synthetic, powder, BioReagent, suitable for cell culture

Szinonimák:

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE₂

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez

About This Item

Tapasztalati képlet (Hill-képlet):

C₂₀H₃₂O₅

CAS Number:

363-24-6

Molekulatömeg:

352.47

Beilstein:

4709356

EC-szám:

206-656-6

MDL-szám:

MFCD00077861

UNSPSC kód:

12352209

eCl@ss:

42020658

PubChem Substance ID:

24898100

NACRES:

NA.77

Fontos dokumentumok

Összes dokumentáció megtekintése

Műszaki ügyfélszolgálat

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Műszaki ügyfélszolgálat

Segítségre van szüksége? Szakértő tudósaink csapata készséggel áll az Ön rendelkezésére.

Segíthetünk?

biológiai forrás

synthetic

Minőségi szint

200

termékcsalád

BioReagent

Teszt

≥93% (HPLC)

Forma

powder

hatékonyság

0.25-100 ng/mL

technika/technikák

cell culture | mammalian: suitable

oldhatóság

acetone: 10 mg/mL, clear, colorless to faintly yellow

kiszállítva

ambient

tárolási hőmérséklet

−20°C

SMILES string

O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O

InChI

1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

Nemzetközi kémiai azonosító kulcs

XEYBRNLFEZDVAW-ARSRFYASSA-N

Géninformáció

human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

Általános leírás

Prostaglandin E2 is a lipid that is obtained from arachidonic acid. Prostaglandin hormone is synthesized by the activity of cycloxygenase-2. Prostaglandin E2 controls inflammatory responses and vascular smooth muscle activity.

Alkalmazás

Prostaglandin E2 has been used as a α-MEM medium supplement for the co-culture of bone marrow macrophages and differentiated osteoblast. It has also been used in the characterization of cells and in vitro decidualization.

Biokémiai/fiziológiai hatások

Most biologically active prostaglandin.

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE₂ on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

Prostaglandin E2 is a signaling molecule produced by activated platelets. The release of PGE2 by activated platelets is part of a mechanism by which activated platelets utilize adjacent erythrocytes to help in clot formation. This product was shown to lower the filterability of human erythrocytes by approximately 30% at a concentration of 10-10sup M and also caused a reduction in mean cell volume by about 10%. The cause of cell shrinkage was the induction of a PGE2- stimulated K+ efflux pathway leading to rapid loss of cellular K+ ions. This loss was shown to be Ca2+dependent. PGE2 has been shown to stimulate the production of interleukin-6 (IL-6) by neonatal mouse parietal bones. After 6 hours in culture, cells stimulated with 10-8sup M PGE2 produced significantly more IL-6 than controls. The pyrogenic activity of PGE2 was not inhibited by dexamethasone, unlike prostaglandin F2α.

Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.