A5835

γ-Aminobutyric acid

≥99%, suitable for ligand binding assays, BioXtra

• Synonym(s): 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid
• Linear Formula: NH₂(CH₂)₃COOH
• CAS Number: 56-12-2
• Molecular Weight: 103.12
• Beilstein: 906818
• EC Number: 200-258-6
• MDL number: MFCD00008226
• UNSPSC Code: 12352106
• PubChem Substance ID: 24891025
• NACRES: NA.26

Properties

• Product Name: γ-Aminobutyric acid, BioXtra, ≥99%
• product line: BioXtra
• Assay: ≥99%
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: <0.0005% Phosphorus (P); <0.1% Insoluble matter
• ign. residue: <0.1%
• color: white
• mp: 195 °C (dec.) (lit.)
• solubility: H₂O: 0.5 M at 20 °C, clear, colorless
• anion traces: chloride (Cl^-): <0.04%; sulfate (SO₄^2-): <0.05%
• cation traces: Al: <5 mg/kg; Ca: <20 mg/kg; Cu: <5 mg/kg; Fe: <5 mg/kg; K: <50 mg/kg; Mg: <50 mg/kg; NH₄⁺: <500 mg/kg; Na: <70 mg/kg; Pb: <10 mg/kg; Zn: <5 mg/kg
• SMILES string: NCCCC(O)=O
• InChI: 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
• InChI key: BTCSSZJGUNDROE-UHFFFAOYSA-N
• Gene Information: human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539) ; rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

Description

General description

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Application

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.

Major inhibitory neurotransmitter in brain; GABA_A and GABA_B receptor agonist; increases Cl⁻ conductance.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves