3570

Glycine

• Synonym(s): Glycine, Gly, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein: 635782
• MDL number: MFCD00008131
• UNSPSC Code: 12352209
• NACRES: NA.54

Properties

• description: RTECS - MB7600000; Merck USA index - 14, 4491
• Quality Level: 100
• Assay: >99% (by assay)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• impurities: ≤100 CFU/g Total microorganism; ≤6.0 EU/g Endotoxin
• color: white
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• solubility: water: 250 mg/mL
• cation traces: Fe: ≤10 ppm; heavy metals (as Pb): ≤5 ppm
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N

Description

General description

A non-essential, optically inactive, non-chiral amino acid. It is the smallest of the 20 natural amino acids. Acts as an inhibitory neurotransmitter, particularly in brain stem and medulla. Shown to block NMDA-stimulated dopamine release in fetal mesencephalic cell cultures. Also reported to increase NMDA-receptor mediated synaptic potential in cortical neurons.

A nonpolar, uncharged amino acid.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Warning

Toxicity: Standard Handling (A)

Other Notes

Shapiro, S. 1997. Neurosurgery 40, 168.
Mount, H., et al. 1991. Mol. Pharmacol.39, 205.
Thompson, A.M., et al. 1989. Nature338, 422.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable