56480

N-Hydroxysuccinimide

≥97.0% (T), for peptide synthesis

• Synonym(s): 1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
• Empirical Formula (Hill Notation): C₄H₅NO₃
• CAS Number: 6066-82-6
• Molecular Weight: 115.09
• Beilstein: 113913
• EC Number: 228-001-3
• MDL number: MFCD00005516
• UNSPSC Code: 12352005
• PubChem Substance ID: 329758217
• NACRES: NA.22

Properties

• Product Name: N-Hydroxysuccinimide, purum, ≥97.0% (T)
• grade: purum
• Quality Level: 200
• Assay: ≥97.0% (T)
• form: solid
• reaction suitability: reaction type: Addition Reactions
• mp: 95-98 °C (lit.); 95-98 °C
• application(s): peptide synthesis
• functional group: imide
• SMILES string: ON1C(=O)CCC1=O
• InChI: 1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
• InChI key: NQTADLQHYWFPDB-UHFFFAOYSA-N

Description

Application

N-Hydroxysuccinimide (NHS) can be used in the following applications:

• To synthesize N-succinimidyl 3-(2-pyridyldithio)-propionate, a heterobifunctional reagent useful for protein-protein conjugation and also to incorporate aliphatic thiols into proteins.
• To synthesize NHS esters of long-chain fatty acids.
• NHS can activate the phosphonic acid monolayers immobilized on titanium surface for binding with proteins.

Other Notes

may contain 1-3% succinic acid and/or succinic anhydride

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H315,H318
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves