8.04518

N-Hydroxysuccinimide

≥99.0% (acidimetric), for peptide synthesis

• Synonym(s): N-Hydroxysuccinimide, 1-Hydroxy-2,5-pyrrolidinedione
• Empirical Formula (Hill Notation): C₄H₅NO₃
• CAS Number: 6066-82-6
• Molecular Weight: 115.09
• MDL number: MFCD00005516
• UNSPSC Code: 12352115
• EC Index Number: 228-001-3
• NACRES: NA.22

Properties

• Product Name: N-Hydroxysuccinimide, for synthesis
• Quality Level: 200
• Assay: ≥99.0% (acidimetric)
• form: crystals
• reaction suitability: reaction type: Addition Reactions
• pH: 5-7 (20 °C, 50 g/L in H₂O)
• mp: 93-100 °C
• application(s): peptide synthesis
• SMILES string: N1(C(=O)CCC1=O)O
• InChI: 1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
• InChI key: NQTADLQHYWFPDB-UHFFFAOYSA-N

Description

Application

• Direct Cα-heteroarylation of structurally diverse ethers: This study showcases a mild N-hydroxysuccinimide mediated cross-dehydrogenative coupling reaction, expanding the utility of NHS in organic synthesis. (Liu et al., 2017).

Analysis Note

Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Identity (IR): passes test

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H315 - H318
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable