D1756

Dexametasona

≥98% (HPLC), powder, NOS induction inhibitor

• Sinónimos: (11β,16α)-9-Fluoro-11,17,21-trihidroxi-16-metilpregna-1,4-dieno-3,20-diona, 9α-Fluoro-16α-metil-11β,17α,21-trihidroxi-1,4-pregnadieno-3,20-diona, 9α-fluoro-16α-metilprednisolona, Prednisolona F
• Fórmula empírica (notación de Hill): C₂₂H₂₉FO₅
• CAS Number: 50-02-2
• Peso molecular: 392.46
• Beilstein: 2066651
• Número CE: 200-003-9
• Número MDL: MFCD00064136
• Código UNSPSC: 51422306
• ID de la sustancia en PubChem: 24893536
• NACRES: NA.77

Propiedades

• Product Name: Dexametasona, ≥98% (HPLC), powder
• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: off-white
• mp: 262-264 °C (lit.)
• solubilidad: methanol: 25 mg/mL
• emisor: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• Clave InChI: UREBDLICKHMUKA-CXSFZGCWSA-N
• Información sobre el gen: human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908) ; mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926) ; rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Descripción

Descripción general

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways, some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

Aplicación

Dexamethasone has been used:

• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
• as a component of adipocyte differentiation medium
• for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

Acciones bioquímicas o fisiológicas

Glucocorticoide antiinflamatorio

Glucocorticoide antiinflamatorio. Regula la supervivencia, el crecimiento y la diferenciación de las células T. Inhibe la inducción de la óxido nítrico sintasa.

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparación

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

Reconstitución

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H360FD
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves