P2307

Polyvinylpyrrolidone

suitable for plant cell culture, average mol wt 10,000

• Synonym(s): PVP, Polyvidone, Povidone
• Linear Formula: (C₆H₉NO)_n
• CAS Number: 9003-39-8
• MDL number: MFCD00149016
• UNSPSC Code: 12352207
• PubChem Substance ID: 24898308
• NACRES: NA.71

Properties

• form: powder
• Quality Level: 200
• mol wt: average mol wt 10,000
• technique(s): cell culture | plant: suitable
• viscosity number: 12-18(lit.)
• SMILES string: C=CN1CCCC1=O
• InChI: 1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
• InChI key: WHNWPMSKXPGLAX-UHFFFAOYSA-N

Description

Application

• Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats.: This study presents the development of a microneedle patch containing Polyvinylpyrrolidone (PVP), which enhances the delivery of anti-obesity medication, showcasing PVP′s utility in pharmaceutical formulations to improve drug solubility and efficacy (Wang H et al., 2024).


• Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer.: This research demonstrates the role of PVP, as a stabilizer and regulator in the synthesis of a nanodrug cocktail, indicating its critical function in nanomedicine for targeting and treating cancer effectively, thereby optimizing therapeutic outcomes (Wang C et al., 2024).


• Biochemical parameters, oxidative stress biomarkers, and anatomopathological changes in Wistar rats treated with 3′-demethoxy-6-O-demethylisoguaiacin and norisoguaiacin.: The study utilizes PVP in biomedical applications, particularly in enhancing the solubility and bioavailability of specific bioactive compounds for therapeutic purposes (Flores Jimenez NG et al., 2024).


• A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats.: Highlighting PVP′s importance in creating water-soluble drug formulations that facilitate the intravenous delivery of hydrophobic substances, this study explores its application in improving drug delivery systems (Rassu G et al., 2024).


• Activation of the PPAR gamma/NF-kB pathway by A-MPDA@Fe(3)O(4)@PVP via scavenging reactive oxygen species to alleviate hepatic ischemia-reperfusion injury.: This innovative study employs PVP to stabilize nanoparticle systems that actively participate in reducing oxidative stress, illustrating PVP′s potential in therapeutic interventions (Mo D et al., 2024).

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves