3867

Hydrocortisone

Steroid hormone of the adrenal cortex with anti-inflammatory properties.

• Synonym(s): Hydrocortisone, Cortisol
• Empirical Formula (Hill Notation): C₂₁H₃₀O₅
• CAS Number: 50-23-7
• Molecular Weight: 362.46
• MDL number: MFCD00011654
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• description: RTECS - GM8925000; Merck USA index - 14, 4787
• Quality Level: 100
• Assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: ethanol: 15 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)[C@H](C2)O)CC1)C)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N

Description

General description

Steroid hormone of the adrenal cortex with anti-inflammatory properties.

Steroid synthesized by the adrenal cortex. Important in the regulation of protein, nucleic acid, and lipid metabolism. Pharmacologically, hydrocortisone is used to suppress the inflammatory response.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Steroid hormone of the adrenal cortex with anti-inflammatory properties

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Preparation Note

Heating to 37°C may be required for complete solubilization.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360Df,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Target Organs: Adrenal gland,Bone marrow
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable