1294284

N-Glycolylneuraminic acid

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 3,5-dideoxy-5-((hydroxyacetyl)amino), D-glycero-D-galacto-2-Nonulosonic acid, Neu5Glc, NeuNGl
• Empirical Formula (Hill Notation): C₁₁H₁₉NO₁₀
• CAS Number: 1113-83-3
• Molecular Weight: 325.27
• Beilstein: 1716828
• MDL number: MFCD00057551
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749945
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: sialic acid
• form: powder
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: −20°C
• SMILES string: [H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O)[C@H](O)[C@H](O)CO
• InChI: 1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1
• InChI key: FDJKUWYYUZCUJX-AJKRCSPLSA-N

Description

General description

This compound is a sialic acid derivative important in various biological processes and is used in research related to glycoproteins.

The USP biologics monoclonal antibodies (mAb) category includes a range of therapeutic proteins that are designed to target specific antigens, providing effective treatments for various diseases, including cancers and autoimmune disorders. Monoclonal antibodies are produced using hybridoma technology and are essential in both diagnostics and therapeutics. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of monoclonal antibody products throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

N-Glycolylneuraminic acid USP reference standard in specified compendial tests and assays.

Also used to prepare standard stock solutions during monosaccharide analysis and analytical procedures for monoclonal antibodies and subtypes according to the given below general chapters of United States Pharmacopeia (USP):

• 〈210〉 Monosaccharide analysis
• 〈129〉 Analytical procedures for recombinant therapeutic monoclonal antibodies

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

This product is part of USP Biologics Program.

This product is part of the USP Biologics program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Sales restrictions may apply.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable