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T6817

Sigma-Aldrich

Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in mouse

clone 28401, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-TNF-α

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About This Item

MDL number:
MFCD00162116
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

28401, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: 4 μg/mL
immunohistochemistry: 25 μg/mL using using fixed human peripheral blood leukocytes and a chromogenic detection system
neutralization: suitable
western blot: 1.0-2.0 μg/mL

isotype

IgG1

UniProt accession no.

P01375

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNF(7124)

Immunogen

recombinant human TNF-α, expressed in E. coli

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Preparation Note

Purified using protein G

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN8093
MKBS4483V
SLBD9802V
021M1311V
079K1768

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Fiorella Calabrese et al.
American journal of respiratory and critical care medicine, 178(9), 894-901 (2008-08-16)
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung, yet the mechanisms that regulate this immune-inflammatory response are not fully understood. We investigated whether IL-32, a newly discovered cytokine, was related to markers of inflammation and
Rosario García-Vicuña et al.
Arthritis and rheumatism, 50(12), 3866-3877 (2004-12-14)
To explore the potential involvement of the chemokine system in synoviocyte-mediated tissue destruction in rheumatoid arthritis (RA), we studied the expression profile of chemokine receptors and their function in the migration, proliferation, and matrix metalloproteinase (MMP) production of cultured fibroblast-like
The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.
C A Smith et al.
Cell, 76(6), 959-962 (1994-03-25)
A Ashkenazi et al.
Science (New York, N.Y.), 281(5381), 1305-1308 (1998-08-28)
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley et al.
Cell, 104(4), 487-501 (2001-03-10)
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