SML4132
Tafamidis meglumine
≥98% (HPLC)
Synonym(s):
2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid mono (1-deoxy-1-methylamino-D-glucitol), Fx 1006A, Fx-1006A, Fx1006A, PF 06291826, PF-06291826, PF06291826
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About This Item
Empirical Formula (Hill Notation):
C21H24Cl2N2O8
CAS Number:
Molecular Weight:
503.33
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to pink
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Biochem/physiol Actions
Transthyretin (TTR) tetramer stabilizer.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.
Caution
Hygroscopic
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