SML4085

Pasireotide Acetate

≥95% (HPLC)

• Synonym(s): Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl] acetate, Cyclo[Phg-DTrp-Lys-Tyr(Bzl)-Phe-(2-aminoethy-carbamoyloxy-Pro)] acetate, SOM 230 acetate, SOM-230 acetate, SOM230 acetate
• Empirical Formula (Hill Notation): C₅₈H₆₆N₁₀O₉ · xC₂H₄O₂
• CAS Number: 1498076-00-8
• Molecular Weight: 1047.21 (free base basis)
• MDL number: MFCD08067735
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Somatostatin (SRIF) eptidomimetic with high affinity for somatostatin receptor subtypes STT1/2/3/5 and in vivo efficacy for suppressing GH secretion.
Pasireotide (SOM230) is a somatostatin (somatotropin release inhibiting factor, SRIF) eptidomimetic with high affinity for somatostatin receptor subtypes STT1/2/3/5 (IC50 = 9.3/1/1.5/0.16 nM), but not STT4 (IC50 > 1 μM). SOM230 potently inhibits the growth hormone (GH) releasing hormone (GHRH)-induced GH release in primary rat pituitary cultures (IC50 = 0:4 nM) and suppresses the secretion of GH, insulin and glucagon in rats in vivo (ED50 in μg/kg post 1h administration via s.c. = 0.22, 3.4, 74, respectively; GH ED50 post 6h = 5.5 μg/kg).

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable