SML4081

Lotilaner

≥98% (HPLC)

• Synonym(s): 5-[(5S)-4,5-Dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-2-thiophenecarboxamide
• Empirical Formula (Hill Notation): C₂₀H₁₄Cl₃F₆N₃O₃S
• CAS Number: 1369852-71-0
• Molecular Weight: 596.76
• MDL number: MFCD32062771
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: FC(F)(F)[C@@]2(ONC(=C2)c3[s]c(c(c3)C)C(=O)NCC(=O)NCC(F)(F)F)c1cc(c(c(c1)Cl)Cl)Cl
• InChI: 1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-5,32H,6-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
• InChI key: DPFOXZCPAGCTER-SFHVURJKSA-N

Description

Biochem/physiol Actions

Orally available and potent inhibitor of γ-aminobutyric acid (GABA)-gated chloride channels; parasiticide.
Lotilaner is an oral isooxazoline ectoparasitic veterinary medication used to control fleas and ticks in dogs and cats. Lotilaner, similarly to other isoxazolines, targets gamma-aminobutyric acid (GABA) receptors. It binds to the GABA-gated chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals and leads to paralysis and death.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable