SML4072
Tetrahydroberberine
≥98% (HPLC)
Synonym(s):
(±)-Canadine, (±)-Tetrahydroberberine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-alpha]quinolizine, Canadine
About This Item
Recommended Products
biological source
(Corydalis yanhusuo)
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
SMILES string
N21C(Cc5c(c(c(cc5)OC)OC)C2)c3c(cc4c(c3)OCO4)CC1
InChI key
VZTUIEROBZXUFA-UHFFFAOYSA-N
Biochem/physiol Actions
Tetrahydroberberine (Canadine), an isoquinoline alkaloid isolated from corydalis tuber, is a potent dopamine D2 receptor antagonist (pKi = 6.08) and nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator. Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia and induces clearance of low-density lipoprotein and intermediate-density lipoprotein in mice.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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