SML3777
SAR7334
≥98% (HPLC)
Synonym(s):
SAR-7334, 4-({(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)-3-chlorobenzonitrile, 4-[rac-trans-(1,2)-2-((R)-3-Aminopiperidin-1-yl)indan-1-yloxy]-3-chlorobenzonitrile, SAR 7334
About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N
InChI key
RLKRLNQEXBPQGQ-OZOXKJRCSA-N
Biochem/physiol Actions
SAR7334 is a TRPC6-selective transient receptor potential channel (TRPC) inhibitor (IC50 against OAG-induced Ca2+ influx in TRPC3/6/7-expressing cells = 9.5/226/282 nM, IC50 >10 μM in TRPC4/10 cells; IC50 = 7.9 nM by whole-cell patch-clamp using TRPC6-HEK-FITR cells).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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