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SML3610

Sigma-Aldrich

Gingerenone A

≥95% (HPLC)

Synonym(s):

(4E)​-1,​7-​bis(4-​hydroxy-​3-​methoxyphenyl)​-4-​Hepten-​3-​one, (E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

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About This Item

Empirical Formula (Hill Notation):
C21H24O5
CAS Number:
128700-97-0
Molecular Weight:
356.41
MDL number:
MFCD06656136
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Gingerenone A is a potent anticancer agent isolated from Ginger (Zingiber officinale) that exhibits minimal toxicity toward normal cells. Gingerenone A potently inhibits JAK2 (Janus Kinase 2) and S6K1 (p70 ribosomal S6 kinase). Gingerenone A significantly suppressed tumor growth in vivo. Also, it exhibits promising senolytic properties. Gingerenone A selectively eliminate senescent cells in WI-38 human fibroblasts rendered senescent by exposure to ionizing radiation.
JAK2 and S6K1inhibitor; anticancer agent isolated from Ginger; it exhibits promising senolytic properties.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Tzu-Jung Yu et al.
Antioxidants (Basel, Switzerland), 11(3) (2022-03-26)
Ginger is a popular spice and consists of several bioactive antioxidant compounds. Gingerenone A (Gin A), a novel compound isolated from Zingiber officinale, is rarely investigated for its anti-breast-cancer properties. Some ginger extracts have been reported to initiate senescence, an
Sanguine Byun et al.
The Journal of biological chemistry, 290(39), 23553-23562 (2015-08-06)
Bioactive phytochemicals can suppress the growth of malignant cells, and investigation of the mechanisms responsible can assist in the identification of novel therapeutic strategies for cancer therapy. Ginger has been reported to exhibit potent anti-cancer effects, although previous reports have

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