SML3520

Talaporfin sodium

≥95% (HPLC)

• Synonym(s): Aspartyl chlorin tetrasodium, LS11 tetrasodium, ME 2906 tetrasodium, ME2906 tetrasodium, Mono-L-aspartyl chlorin tetrasodium, Mono-L-aspartyl chlorin e6 tetrasodium, NPe6 tetrasodium, Talaporfin tetrasodium, N-[[(7S,8S)-3-Carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid, tetrasodium salt
• Empirical Formula (Hill Notation): C₃₈H₃₇N₅Na₄O₉
• CAS Number: 220201-34-3
• Molecular Weight: 799.69
• MDL number: MFCD26960899
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: , Dark green to black
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: O=C(C[C@H](NC(C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C(C(O[Na])=O)=C1N5)C)=N\2)=O)C(O[Na])=O)O[Na]

Description

Biochem/physiol Actions

Cancer tissue-targeting photosensitizer that induces irradiation-dependent cancer killing and in vivo photodynamic therapy (PDT) efficacy.

Talaporfin is a chlorin based cancer tissue-targeting photosensitizer that, upon irradiation, generates reactive oxygen species (ROS) that cause DNA damage and apoptosis in cancer cells. Talaporfin induces irradiation-dependent cancer killing in cultures (24 h 10-100 μg/mL Talaporfin sodium followed by washing and 664 nm laser irradation at 15 mW/cm2 and 10 J/cm2; ESCC) and displays photodynamic therapy (PDT) efficacy in human cancer exnograft models in mice in vivo, including EMT-6 sarcoma (100% cure with 664 nm laser at 100 J/cm2 and 100 mw/cm2 24h after 8 mg/kg talaporfin i.p.) and ESCC (664 nm, 100 J/cm2 2h after 10 mg/kg talaporfin sodium via tail vein i.v.).

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable