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SML3498

Sigma-Aldrich

L6H21

≥98% (HPLC)

Synonym(s):

(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one, (E)-2,3,4′-Trimethoxy-chalcone, (E)-2,3-Dimethoxy-4′-methoxychalcone, L 6H21

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About This Item

Empirical Formula (Hill Notation):
C18H18O4
CAS Number:
24533-47-9
Molecular Weight:
298.33
MDL number:
MFCD01901426
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

L6H21 is an orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist and shows a great inhibitory effect on pro-inflammatory cytokines expression levels. L6H21 binds to the hydrophobic pocket of MD2 in a dose-dependent manner with a high affinity (Kd = 33.3 µM) and inhibits the ability of LPS to recognize TLR4/MD2 complex. Suppresses NLRP3 inflammasome activation and may serve as a potential candidate for the treatment of allograft rejection.
Orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H400

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Huaicheng Chen et al.
Experimental & molecular medicine, 53(4), 681-694 (2021-04-21)
Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that modified LDL activates Toll-like receptor 4 (TLR4) to mediate retinal injury. However, the mechanism by which modified LDL activates TLR4

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