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Key Documents

SML0910

Sigma-Aldrich

TC3.6

≥98% (HPLC)

Synonym(s):

3-Phenyl-2,4(1H,3H)-quinazolinedithione

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About This Item

Empirical Formula (Hill Notation):
C14H10N2S2
CAS Number:
16081-93-9
Molecular Weight:
270.37
UNSPSC Code:
41106305
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

light orange to dark orange

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

Sc1[n]([c](c3c(n1)cccc3)=S)c2ccccc2

InChI key

DJJOAJCVIYRELX-UHFFFAOYSA-N

Biochem/physiol Actions

TC3.6 is a PDE7 selective inhibitor (IC50 = 1.04 μM). In an Experimental Autoimmune Encephalomyelitis (EAE) murine model, TC3.6 reduced levels of IL-17, blocked infiltration of immune cells into the CNS and elevated levels of the Treg marker Foxp3. TC3.6 also enhances survival and differentiation of oligodendrocyte precursor cells.
TC3.6 is a PDE7 selective inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
123M4602V

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Articles

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

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