SBR00098

Tazemetostat

≥98% (HPLC), powder

• Synonym(s): EPZ6438
• Empirical Formula (Hill Notation): C₃₄H₄₄N₄O₄
• CAS Number: 1403254-99-8
• Molecular Weight: 572.74
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• Mode of action: protein synthesis | inhibits
• storage temp.: 2-30°C
• SMILES string: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
• InChI: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
• InChI key: NSQSAUGJQHDYNO-UHFFFAOYSA-N

Description

General description

Tazemetostat is a small molecule inhibitor of the EZH2 protein, which is a histone-lysine N-methyltransferase enzyme that plays a key role in epigenetic regulation of gene expression.

Biochem/physiol Actions

Tazemetostat inhibits the EZH2 protein. EZH2 is a histone-lysine N-methyltransferase enzyme that plays a key role in epigenetic regulation of gene expression in cells. As an epigenetic modifier, EZH2 protein controls the transcriptional repression of various genes involved in cell cycle regulation, DNA repair, and other cellular processes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable