SBR00080

Dolutegravir

• Synonym(s): GSK 1349572
• Empirical Formula (Hill Notation): C₂₀H₁₉F₂N₃O₅
• CAS Number: 1051375-16-6
• Molecular Weight: 419.38
• UNSPSC Code: 51101500

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• color: white to off-white
• antibiotic activity spectrum: viruses
• Mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
• InChI: 1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
• InChI key: RHWKPHLQXYSBKR-BMIGLBTASA-N

Description

General description

Dolutegravir is an antibioitic which belongs to the class of compounds known as integrase strand transfer inhibitors (INSTIs).

Biochem/physiol Actions

Dolutegravir inhibits HIV-1 viral replication, high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants. Dolutegravir inhibitis the action of the HIV integrase enzyme, which is necessary for the integration of viral DNA into the host genome, thereby preventing viral replication and reducing HIV viral load.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable