SAB6010095

Anti-phospho-MLKL (S358) antibody, clone 4A6, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonym(s): Mixed lineage kinase domain-like protein, hMLKL, MLKL
• UNSPSC Code: 12352203

Properties

• recombinant: expressed in HEK 293 F cells
• Quality Level: 100
• conjugate: unconjugated
• antibody product type: primary antibodies
• clone: 4A6, recombinant monoclonal
• form: liquid
• mol wt: 150 kDa
• purified by: affinity chromatography
• species reactivity: human
• concentration: 1.6mg/ml
• technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• isotype: IgG
• UniProt accession no.: Q8NB16
• shipped in: wet ice
• storage temp.: -10 to -25°C
• target post-translational modification: phosphorylation (pSer358)

Description

General description

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Immunogen

A synthesized peptide derived from human Phospho-MLKL (S358)

Sequence

344-389aa

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage and Stability

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable