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C6617

Sigma-Aldrich

CBIQ

≥98% (HPLC), solid

Synonym(s):

4-Chlorobenzo[f]isoquinoline

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About This Item

Empirical Formula (Hill Notation):
C13H8NCl
CAS Number:
32081-28-0
Molecular Weight:
213.66
MDL number:
MFCD02179769
UNSPSC Code:
12352200
PubChem Substance ID:
24724450
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: 15 mg/mL

SMILES string

Clc1nccc2c1ccc3ccccc23

InChI

1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H

InChI key

SHQLTRRYZVBEMR-UHFFFAOYSA-N

Biochem/physiol Actions

CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K+ channel (KCNN4) activator.
CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Features and Benefits

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H301,H315,H318,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
036K47071
036K4707

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Articles

Chloride Channels

Sigma-Aldrich offers many products related to chloride channels for your research needs.

Potassium Channels

Sigma-Aldrich offers many products related to potassium channels for your research needs.

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