SCC439

SK-MEL-103 Human Melanoma Cell Line 

• Synonym(s): K-Mel-103, SKMEL-103, SKMEL103, SkMel103
• UNSPSC Code: 41106514

Properties

• biological source: human
• Quality Level: 100
• packaging: vial of ≥1 x 10^6 vial (viable cells per vial)
• manufacturer/tradename: Millipore
• technique(s): cell culture | mammalian: suitable
• shipped in: liquid nitrogen
• storage temp.: −196°C

Description

Application

• Each vial contains > 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Essential CLEAR Panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for interspecies contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
• Cells are negative for mycoplasma contamination.

Features and Benefits

SK-MEL-103 is a human metastatic melanoma cell line that retains a Q61R NRAS mutation which is associated with a more aggressive phenotype, higher metastasis risk, and therefore a poorer prognosis.

Target description

Melanoma is considered the most dangerous form of skin cancer. It develops in melanocytes, the pigment producing cells of the skin. Melanoma accounts for a very small number of all skin cancers. Even though it accounts for only around 1% of total diagnosed skin cancer cases, it also results in the largest number of skin cancer deaths.3 Incidence rates have increased over time, however, mortality rates from melanoma have improved over the last decade due to advances in treatment.

SK-MEL-103 is a human metastatic melanoma cell line. It retains a Q61R NRAS mutation which is associated with a more aggressive phenotype, higher metastasis risk, and therefore a poorer prognosis.1 While there has been an improvement in understanding BRAF-mutant melanoma and its therapeutic strategies, solutions to NRAS-mutant melanoma have remained limited. Further development of immune therapies for NRAS-specific mutants remains highly relevant.

Source
Non-GMO
Cell line sourced from human melanoma.

References
1. Muñoz-Couselo E, Adelantado EZ, Ortiz C, García JS, Perez-Garcia J. NRAS-mutant melanoma: current challenges and future prospect. Onco Targets Ther. 2017 Aug 8;10:3941-3947. doi: 10.2147/OTT.S117121. PMID: 28860801; PMCID: PMC5558581.

Storage and Stability

SK-MEL-103 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable