T2376

L-Thyroxine

≥98% (HPLC)

• Sinônimo(s): 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Fórmula linear: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS Number: 51-48-9
• Peso molecular: 776.87
• Beilstein: 2228515
• Número CE: 200-101-1
• Número MDL: MFCD00002595
• Código UNSPSC: 51111800
• ID de substância PubChem: 24900033
• NACRES: NA.32

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 200
• esterilidade: non-sterile
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• pf: 223 °C (dec.) (lit.)
• solubilidade: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow
• Condições de expedição: ambient
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• chave InChI: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• Informações sobre genes: human ... THRA(7067), THRB(7068), TTR(7276) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Descrição

Aplicação

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

Ações bioquímicas/fisiológicas

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparo

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H372
• Declarações de precaução: P260 - P264 - P270 - P314 - P501
• Classificações de perigo: STOT RE 1
• Órgãos-alvo: Thyroid,Cardio-vascular system,Kidney
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)