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SRP2140

Sigma-Aldrich

PPAR γ, ligand binding domain (204-477), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.26
Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

Assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~57.8 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

450 μg/mL

color

clear colorless

NCBI accession no.

NM_138712

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Milligard® LPB 0.5/0.2 µm nominal, Opticap® XL Capsule

Milligard® LPB 0.5 µm nominal, Opticap® XL Capsule inlet connection diam. 1.5 in., Opticap® XL 2, pore size 0.5 μm, cartridge nominal length 2 in. (5 cm)

KWL6A02TT3

Milligard® LPB 0.5 µm nominal, Opticap® XL Capsule

Milligard® LPB 1.2/0.5 µm nominal, Opticap® XL Capsule Opticap® XL 2, inlet connection diam. 1.5 in., pore size 1.2/0.5 μm, cartridge nominal length 2 in. (5 cm)

KWLCA02TT3

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technique(s)

prefiltration: suitable

technique(s)

prefiltration: suitable

technique(s)

prefiltration: suitable

technique(s)

prefiltration: suitable

product line

Opticap® XL 2

product line

Opticap® XL 2

product line

Opticap® XL 2

product line

Opticap® XL 2

filtration area

0.07 m2

filtration area

0.07 m2

filtration area

0.07 m2

filtration area

0.07 m2

manufacturer/tradename

Opticap®

manufacturer/tradename

Opticap®

manufacturer/tradename

Opticap®

manufacturer/tradename

Opticap®

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9- cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPARα is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPARγ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. PPARγ influences the storage of fatty acids in the adipose tissue. With the C/EBP transcription factors, PPARγ is part of the adipocyte differentiation program that induces the maturation of pre-adipocytes into fat cells. Most of the PPARγ target genes in adipose tissue are directly implicated in lipogenic pathways, including lipoprotein lipase (LPL), adipocyte fatty acid binding protein (A-FABP or AP2), acyl-CoA synthase and fatty acid transport protein (FATP). In addition, PPARγ is a direct target gene of the transcription factor sterol response element binding protein 1 (SREBP1) emphasizing the cooperative and additive functions between these two types of receptor.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    117012073

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    E D Rosen et al.
    Molecular cell, 4(4), 611-617 (1999-11-05)
    The process of adipogenesis is known to involve the interplay of several transcription factors. Activation of one of these factors, the nuclear hormone receptor PPAR gamma, is known to promote fat cell differentiation in vitro. Whether PPAR gamma is required
    Peroxisome proliferator-activated receptors: nuclear control of metabolism.
    B Desvergne et al.
    Endocrine reviews, 20(5), 649-688 (1999-10-26)
    S Kersten et al.
    Nature, 405(6785), 421-424 (2000-06-06)
    In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called

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