SBR00089

Sotorasib

≥98% (HPLC), solid

• Synonym(s): AMG-510
• Empirical Formula (Hill Notation): C₃₀H₃₀F₂N₆O₃
• CAS Number: 2252403-56-6
• Molecular Weight: 560.59
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: off-white to yellow
• Mode of action: protein synthesis | inhibits
• SMILES string: C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
• InChI: InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
• InChI key: NXQKSXLFSAEQCZ-SFHVURJKSA-N

Description

General description

Sotorasib (INN) is a small molecule which belongs to the class of compounds known as KRAS G12C inhibitors. Sotorasib is a chiral compound which is a KRAS G12C covalent inhibitor.

Biochem/physiol Actions

Sotorasib inhibits the KRAS G12C protein, which is involved in the regulation of cell growth and division. The KRAS G12C protein is a mutated form of the KRAS protein, which is found in certain types of cancer cells, particularly non-small cell lung cancer (NSCLC). The G12C mutation causes abnormal activation of the KRAS G12C protein, leading to the uncontrolled growth and spread of cancer cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable