M4008

Morin hydrate

powder

• Synonym(s): 2′,3,4′,5,7-Pentahydroxyflavone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₇ · xH₂O
• CAS Number: 654055-01-3
• Molecular Weight: 302.24 (anhydrous basis)
• EC Number: 207-542-9
• MDL number: MFCD00217054
• UNSPSC Code: 12171500
• PubChem Substance ID: 24278552
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 100
• color: yellow
• solubility: methanol: 50 mg/mL
• SMILES string: O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2
• InChI key: MYUBTSPIIFYCIU-UHFFFAOYSA-N

Description

Application

Morin hydrate has been used:

• to investigate its antitumor functionality using cell viability and apoptosis assay in human cancer cell lines.
• as a fluorescence stain to detect aluminum in motor neurons and lumbar cord.
• to study its protective effect on neuronal hearing loss and on neural stem cells (NSCs) proliferation and differentiation

Biochem/physiol Actions

Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At concentrations of 75-100 micromolar, morin inhibits oxidation of low density lipoprotein (LDL) by free radicals or Cu²⁺. Morin has been reported to inhibit rat brain phospha­tidyl­inositol­phos­phate kinase activity in vitro and in vivo.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves