362000

N-Glycolylneuraminic Acid

Formed by the action of CMP-Neu5Ac hydroxylase. Humans are devoid of this compound due to a mutation in the human CMP-Neu5Ac hydroxylase gene that occurred after the Homo-Pan divergence.

• Synonym(s): N-Glycolylneuraminic Acid, NeuGc, Neu5Gc
• Empirical Formula (Hill Notation): C₁₁H₁₉NO₁₀
• CAS Number: 1113-83-3
• Molecular Weight: 325.27
• MDL number: MFCD00057551
• UNSPSC Code: 12352201
• NACRES: NA.79

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: N([C@@H]([C@@H](O)[C@H](O)[C@H](O)CO)[C@@H](O)C(=O)C(=O)O)C(=O)CO
• InChI: 1S/C10H17NO10/c12-1-3(14)6(16)7(17)5(11-4(15)2-13)8(18)9(19)10(20)21/h3,5-8,12-14,16-18H,1-2H2,(H,11,15)(H,20,21)/t3-,5+,6-,7-,8-/m1/s1
• InChI key: YIICUBSXBNCXHW-BOSCHMPASA-N

Description

General description

Formed by the action of CMP-Neu5Ac hydroxylase. A major component in great ape tissues except brain; however, it is absent in man due to a mutation in the human CMP-Neu5Ac hydroxylase gene that is reported to have occurred after the Homo-Pan divergence.

Warning

Toxicity: Standard Handling (A)

Other Notes

Chou, H.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 11751.
Malykh, Y.N., et al. 1998. Glycoconj. J. 15, 885.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable