1.07098

8-Hydroxyquinoline

GR for analysis Reag. Ph Eur

• Synonym(s): 8-Hydroxyquinoline, Oxine, 8-Quinolinol
• Empirical Formula (Hill Notation): C₉H₇NO
• CAS Number: 148-24-3
• Molecular Weight: 145.16
• MDL number: MFCD00006807
• UNSPSC Code: 12352104
• EC Index Number: 205-711-1
• NACRES: NA.21

Properties

• Agency: reag. Ph. Eur.
• Quality Level: 200
• form: solid
• potency: 1200 mg/kg LD₅₀, oral (Rat)
• bp: 267 °C/1013 hPa
• mp: 72.5-74.0 °C
• density: 1.034 g/cm³ at 20 °C
• storage temp.: 15-25°C
• SMILES string: n1c2c(ccc1)cccc2O
• InChI: 1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
• InChI key: MCJGNVYPOGVAJF-UHFFFAOYSA-N

Description

Application

• Pseudo-water-soluble Fe(2)O(3) as Nanozyme catalyzed chemiluminescent reaction for detection of brilliant blue in gelatin and beverages.: This innovative study utilizes 8-Hydroxyquinoline for enhancing chemiluminescent reactions in the detection of food colorants, presenting a new avenue in food safety and quality assurance techniques (Jabbar HS, 2024).


• Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives.: Incorporating 8-Hydroxyquinoline in the development of zinc(II)-Schiff base complexes, this research demonstrates potential therapeutic applications in targeting melanoma cells, highlighting its role in medicinal chemistry (Côrte-Real et al., 2024).


• Synthesis, crystal structure and anti-cancer activity of the complex chlorido-(η(2)-ethyl-ene)(quinolin-8-olato-κ(2)N,O)platinum(II) by experimental and theoretical methods.: This paper details the synthesis and anti-cancer properties of a novel platinum(II) complex using 8-Hydroxyquinoline, offering insights into its structural characteristics and therapeutic potential (Chi NTT et al., 2024).


• Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.: Exploring the use of 8-Hydroxyquinoline in rhodium(III) complexes, this study provides a new perspective on targeting cancer cell metabolism, specifically through mitophagy pathways (Huang XQ et al., 2024).


• Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.: This research examines the effectiveness of 8-Hydroxyquinoline complexes in inducing ferroptosis in cancer cells, a novel approach in cancer therapy focusing on oxidative cell death mechanisms (Meng T et al., 2024).

Analysis Note

Assay (perchloric acid titration): ≥ 99
Identity (IR-spectrum): passes test
Matter insoluble in ethanol: ≤ 0.05 %
Melting point: 73 - 75 °C
Chloride (Cl): ≤ 0.001 %
Sulfate (SO₄): ≤ 0.01 %
Sulfated ash: ≤ 0.05 %
Suitability as reagent (for Mg-test): passes test

Safety Information

• Pictograms: GHS05,GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301 - H317 - H318 - H360D - H410
• Precautionary Statements: P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable