NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Synonyms:
EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
Species:
Human NFKB1 (4790), Mouse Nfkb1 (18033), Rat Nfkb1 (81736), sheep NFKB1 (101108228), domestic guinea pig Nfkb1 (100730075), naked mole-rat Nfkb1 (101696485), Zebrafish nfkb1 (565756), chicken NFKB1 (396033), dog NFKB1 (442859), cow NFKB1 (616115)
UniProtKB ID:
Gene ID:
- Human(4790) Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Mouse(18033) nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
- Rat(81736) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- sheep(101108228) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- domestic guinea pig(100730075) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- naked mole-rat(101696485) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- Zebrafish(565756) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- chicken(396033) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- dog(442859) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- cow(616115) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- domestic cat(100142683) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NF-kB p50/105 Antibody, clone 1N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-NFκB p50 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, rhesus macaque
Application
immunoprecipitation (IP)
western blot
western blot
Anti-NFκB p65 Antibody, CT, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
electrophoretic mobility shift assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho-NF-kB (p100) (Ser707) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
dot blot
inhibition assay
western blot
inhibition assay
western blot
Anti-NFκB Antibody, p65 subunit, active subunit, clone 12H11, clone 12H11, Chemicon®, from mouse,
Species Reactivity
human, mouse, rabbit, rat
Application
electrophoretic mobility shift assay
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot