Name: MG-132(R)
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₄₁N₃O₅

CAS Number:

1211877-36-9

Molecular Weight:

475.62

MDL number:

MFCD28580122

UNSPSC Code:

12352200

PubChem Substance ID:

329825671

NACRES:

NA.32

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product line

SAFC Hitech^®

Quality Level

200

Assay

≥95% (HPLC)

form

powder

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-ZRBLBEILSA-N

Gene Information

human ... CTSB(1508), NFKB1(4790), PSMA1(5682)

Related Categories

Amino Acids

Bioactive Small Molecules

Biochemicals

Cell Culture Supplements & Reagents

Biochem/physiol Actions

MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.

Legal Information

SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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