SPHK1
sphingosine kinase 1
Synonyms:
SPHK
Species:
Human SPHK1 (8877), Mouse Sphk1 (20698), Rat Sphk1 (170897), Thale Cress SPHK1 (828239), chicken SPHK1 (427803), dog SPHK1 (483329), domestic cat SPHK1 (101084918), Horse SPHK1 (100058875), cow SPHK1 (618605), sheep SPHK1 (101105263) ...More
UniProtKB ID:
Gene ID:
- Human(8877) Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- Mouse(20698) sphingosine kinase 1
- Rat(170897) sphingosine kinase 1
- Thale Cress(828239) sphingosine kinase 1
- chicken(427803) sphingosine kinase 1
- dog(483329) sphingosine kinase 1
- domestic cat(101084918) sphingosine kinase 1
- Horse(100058875) sphingosine kinase 1
- cow(618605) sphingosine kinase 1
- sheep(101105263) sphingosine kinase 1
- domestic guinea pig(100727266) sphingosine kinase 1
- naked mole-rat(101711606) sphingosine kinase 1
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