Skip to Content
Merck

SETMAR

SET domain and mariner transposase fusion gene

Synonyms:
HsMar1, METNASE, Mar1
Species:
Human SETMAR (6419), Mouse Setmar (74729), Rat Setmar (500281), naked mole-rat Setmar (101704237), cow SETMAR (511299), sheep SETMAR (101110273), Zebrafish setmar (564575), domestic cat SETMAR (101088560), dog SETMAR (476549)
UniProtKB ID:
Q53H47, Q13579, Q1G668, Q96F41
Gene ID:
  • Human(6419) Summary: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
  • Mouse(74729) SET domain without mariner transposase fusion
  • Rat(500281) SET domain without mariner transposase fusion
  • naked mole-rat(101704237) SET domain and mariner transposase fusion gene
  • cow(511299) SET domain without mariner transposase fusion
  • sheep(101110273) SET domain gene
  • Zebrafish(564575) SET domain without mariner transposase fusion
  • domestic cat(101088560) SET domain without mariner transposase fusion
  • dog(476549) SET domain without mariner transposase fusion

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
HPA057999
Anti-SETMAR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
SAB4301723
Anti-SETMAR, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
SAB1406427
Anti-SETMAR antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Proteins

Product Number
Description
Species
SRP5262
SETMAR, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
SRP0165
Metnase (SETMAR) human, recombinant, expressed in FreeStyle™ 293-F cells, ≥30% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EMU169171
MISSION® esiRNA, targeting mouse Setmar,
Species
mouse
EHU017141
MISSION® esiRNA, targeting human SETMAR,
Species
human