PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Synonyms:
FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E
Species:
Human PTPN13 (5783), Mouse Ptpn13 (19249), Rat Ptpn13 (498331), naked mole-rat Ptpn13 (101715582), domestic guinea pig Ptpn13 (100717744), cow PTPN13 (282333), sheep PTPN13 (101121266), Zebrafish ptpn13 (560883), domestic cat PTPN13 (100144609), dog PTPN13 (403662)
UniProtKB ID:
Gene ID:
- Human(5783) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
- Mouse(19249) protein tyrosine phosphatase, non-receptor type 13
- Rat(498331) protein tyrosine phosphatase, non-receptor type 13
- naked mole-rat(101715582) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- domestic guinea pig(100717744) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- cow(282333) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- sheep(101121266) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- Zebrafish(560883) protein tyrosine phosphatase, non-receptor type 13
- domestic cat(100144609) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- dog(403662) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- chicken(422591) protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PTPN13 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PTPN13 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-PTPN13 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Proteins
Product Number
Description
Species
PTPN13 (2169-2485), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human