BEST1
bestrophin 1
Synonyms:
ARB, BEST, BMD, RP50, TU15B, VMD2
Species:
Human BEST1 (7439), Mouse Best1 (24115), Rat Best1 (293735), fruit fly Best1 (53431), cow BEST1 (508924), Horse BEST1 (100059901), dog BEST1 (483791), domestic cat BEST1 (101084904), chicken BEST1 (423124), naked mole-rat Best1 (101710606) ...More
UniProtKB ID:
Gene ID:
- Human(7439) Summary: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
- Mouse(24115) bestrophin 1
- Rat(293735) bestrophin 1
- fruit fly(53431) Bestrophin 1
- cow(508924) bestrophin 1
- Horse(100059901) bestrophin 1
- dog(483791) bestrophin 1
- domestic cat(101084904) bestrophin 1
- chicken(423124) bestrophin 1
- naked mole-rat(101710606) bestrophin 1
- domestic guinea pig(100723621) bestrophin 1
- sheep(101109837) bestrophin 1
- Domestic Rabbit(100352203) bestrophin 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-VMD2 antibody produced in mouse, clone 1C2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-BEST1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-Bestrophin Antibody, Chemicon®, from mouse,
Species Reactivity
bovine, human, monkey, mouse, pig
Application
immunohistochemistry
western blot
western blot